Naproxen is an NSAID (nonsteroidal anti-inflammatory drug) used to reduce pain, swelling, and fever. You’ll see it sold as Aleve (naproxen sodium), Naprosyn, or generic naproxen. People use it for headaches, muscle aches, arthritis, period pain, and minor injuries. It works by blocking chemicals that cause inflammation and pain.
Take naproxen with food or a glass of milk to cut down stomach upset. For over‑the‑counter naproxen sodium (Aleve), the usual dose is 220 mg every 8–12 hours; a first dose may be 440 mg. Don’t take more than 660 mg in 24 hours without medical advice. Prescription naproxen doses are higher and vary by condition—follow your doctor’s directions.
Space doses evenly and avoid taking other NSAIDs (like ibuprofen or ketoprofen) at the same time. If you already take low‑dose aspirin for the heart, talk to your doctor before using naproxen—mixing painkillers can raise bleeding risk or reduce aspirin’s benefit.
Stomach pain, heartburn, and nausea are common. The bigger risks are stomach ulcers, internal bleeding, kidney problems, and higher chance of heart attack or stroke with long‑term or high‑dose use. If you notice black stools, severe belly pain, sudden weakness, shortness of breath, or chest pain, get medical help right away.
Avoid naproxen if you have active stomach ulcers, severe heart failure, or an allergy to NSAIDs. Pregnant people should not use naproxen in the third trimester because it can harm the baby or complicate delivery. Older adults may be more sensitive to side effects—start at the lowest effective dose and check with a clinician.
Drug interactions matter. Naproxen can increase bleeding with blood thinners (warfarin), raise lithium and methotrexate levels, and reduce the effectiveness of some blood pressure medicines (ACE inhibitors, ARBs, or certain diuretics). SSRIs and SNRIs plus naproxen raise bleeding risk. Always tell your prescriber about every medicine and supplement you take.
Short tip: if you need regular pain control for arthritis, discuss long‑term plans with your doctor. They may recommend the lowest effective dose, protective measures (like stomach‑protecting drugs), or alternative therapies if risks are high.
If pain suddenly gets worse, new symptoms appear, or you’re unsure about dosing, contact a healthcare professional. Naproxen is effective, but like all medicines, it works best when used carefully and with clear medical guidance.
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