Domperidone: What it does, who uses it, and what to watch for

Domperidone is a medicine doctors use to fight nausea, help slow stomach emptying, and sometimes boost breast milk supply. It works by blocking dopamine receptors in the gut, which helps speed up digestion and reduce feelings of nausea. In many countries it’s a common option for gastroparesis and chemotherapy-related nausea; for lactation support it’s used off-label under medical supervision.

There’s a sharp safety angle you should know. Regulators in some places have warned that domperidone can change heart rhythm, especially at higher doses, in older adults, or when combined with certain drugs. Common, milder side effects are dry mouth, stomach cramps, and headache. Less common but more serious effects include irregular heartbeat or fainting—those need immediate medical attention.

How doctors typically prescribe it

Dosing varies by country and condition. Many prescribers use 10 mg once or twice before meals, sometimes up to three times daily when needed, but rules differ and some places limit duration. For digestive issues, clinicians aim for the lowest effective dose for the shortest time. When used to support lactation, doctors often try a short trial and reassess quickly. Never change dose or stop/start without talking to your prescriber.

Drug interactions, tests, and precautions

Domperidone can interact with drugs that raise its blood level or prolong the QT interval. Examples include some antifungals, certain antibiotics like erythromycin, and strong CYP3A4 inhibitors. Many antidepressants and antipsychotics can also increase heart risk when combined. If you have heart disease, low potassium, or take multiple medicines, your doctor may order an ECG or blood tests first.

Compare it to metoclopramide: both speed gastric emptying, but metoclopramide crosses into the brain more and can cause movement-related side effects. That difference is why one might be preferred over the other depending on your health profile.

Buying and legal status: a prescription is required in most countries. Domperidone is available under brand names like Motilium in many places but is not approved everywhere. If you look online, pick pharmacies with verifiable credentials, ask for a prescription, and avoid sites that promise delivery without checks. Our site has guides on verifying online pharmacies and safe ordering practices.

Simple, practical tips: take the pill before meals if used for digestive symptoms; report palpitations, dizziness, or fainting right away; try non-drug measures for milk supply before starting medication. Always ask your prescriber why they recommend domperidone, how long you should take it, and whether any tests are needed first. Getting clear answers helps you weigh benefits and risks without surprises.