Nattokinase: August 2023 Archive — Improve Blood Flow and Reduce Inflammation

This month we published a practical guide on nattokinase, a supplement made from fermented soy that many use to support circulation and ease inflammation. If you read one piece from August 2023, make it this clear, actionable overview. I explain what nattokinase does, who might try it, safe dosing ranges, and what to watch for when mixing with other drugs.

Nattokinase is an enzyme produced during the fermentation of soybeans into natto, a traditional Japanese food. It helps break down fibrin, a protein involved in blood clot formation. That action can improve blood flow and may reduce swelling tied to inflammation. A small clinical trial and several lab studies showed improvements in markers of clot breakdown and inflammation, but nattokinase is not a replacement for prescribed blood-thinners.

How people use it and how much to take

Most supplements list activity in fibrinolytic units (FU) rather than milligrams. Common doses range from 2,000 to 4,000 FU taken once or twice daily with water on an empty stomach for best absorption. Some people notice mild benefits within weeks, while others need consistent use for two to three months. If you try nattokinase, start low and track changes in energy, circulation, or swelling.

Safety, interactions, and practical tips

Don’t take nattokinase if you are on anticoagulant drugs like warfarin, direct oral anticoagulants, or aspirin without talking to your doctor. Combining nattokinase with blood-thinners raises bleeding risk. Also avoid it before surgery. Side effects are usually mild — stomach upset or allergic reaction in people sensitive to soy. Choose products from reputable brands that list FU activity and third-party testing for purity.

Look for nattokinase made from non-GMO soy if that matters to you, and check for added fillers. Keep a symptom diary for the first month to notice improvements or side effects. If you have high blood pressure, diabetes, or cardiovascular disease, ask your healthcare provider whether nattokinase fits into your care plan and whether any lab monitoring is needed.

Our August post gives a straightforward breakdown of studies that measured clot-related markers and inflammation, with citations you can check. The article also explains how nattokinase compares to other supplements like fish oil and turmeric, which help inflammation through different mechanisms. If you want a supplement that targets fibrin and circulation specifically, nattokinase is worth a look — just be cautious around blood-thinning medications.

Combine nattokinase with simple lifestyle steps to get better results: daily brisk walking, staying hydrated, and eating anti-inflammatory foods like leafy greens and fatty fish. Store supplements in a cool, dry place, check expiration dates, and keep a list of all supplements and medications for your doctor. Small habits multiply benefits over time.

Want the full article? Read "The Nattokinase Advantage" to see practical dosing examples, study highlights, and product tips we used when reviewing brands this month. If you have personal experience or questions, drop a comment on the post so the community and our editors can respond.